Barely Significant
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Monocyte migration assay using a vascular-on-a-chip model and its utilization for the evaluation of a heated tobacco product.

Front Toxicol · 2025 · PMC12711516 · PMID 41424804

Europe PMCDOI
1
hedged sentence
0.9156
closest p · 18.3× alpha
0.9156
boldest claim

The sentences

did not reach statistical significancep = 0.9156not close (p > 0.1)
Although the comparison between the LPS-exposed M1MΦs and 1% DMSO-treated M1MΦs did not reach statistical significance ( p = 0.9156), the potential cytotoxicity of LPS compared with 1% DMSO was indicated by the effect size ( r = 0.8449). 3.3 The effect of LPS-exposed M1MΦ secretions on TEER and monocyte adhesion and migration To confirm our VoC model replicates monocyte migration induced by inflammatory activated M1MΦs, HCAECs were exposed to LPS-conditioned medium for 24 h to mimic inflammatory conditions in the vasculature of patients with atherosclerosis.

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