Multi-omics factor analysis identifies the Tensin 1-Fermitin family homologue 2-Fibronectin 1-Integrin signaling axis as a prognostic determinant in colorectal cancer.

Although the prognostic effect in the CPTAC-2 discovery cohort did not reach statistical significance, this likely reflects limited follow-up and sample size rather than biological irrelevance, as suggested by the successful cross-cohort replication.

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