Co-targeting CDK4/6 enhances anti-cancer activity and alleviates immune-related adverse events of anti-PD-1 antibody for breast cancer.

Results Exposure to DEHP was associated with early tumorigenesis and low tumor infiltration of lymphocytes of human breast tumors First, we observed that tumor infiltration of CD3 + , cytotoxic CD8 + , and cytotoxic granzyme B + (GZMB + ) lymphocytes showed a trend in positive correlation with diagnosis age ( Figure S1 A), suggesting the involvement of immune dysfunction in certain populations of EOBC patients.

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