The comprehensive oral microbiome landscape unveils its interplay with poor oral health in esophageal squamous cell carcinoma risk.

Cell Rep Med · 2025 · PMC12711725 · PMID 41197616

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borderline significantno p-value reported

gingivalis , a borderline significant enrichment in T. denticola ( q = 0.052) and two other periodontal pathogens ( q < 0.05), P. catoniae and T. sp oral taxon HOT 286 , 30 was identified in ESCC cases.

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showed a trendno p-value reported

mitis showed a trend toward positive association with both poor oral health and ESCC ( Figures S6 A, S13 B, and S13C).

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borderline significanceno p-value reported

Moreover, the associations between ESCC and oral health indicators, including oral health risk score ( p interaction = 0.008), missing and filled teeth ( p interaction = 0.009), and tooth brushing frequency (borderline significance, p interaction = 0.180), were more pronounced in participants with low S. mitis levels ( Figures 5 C and S12 B).

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