A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study.

Adv Biol (Weinh) · 2025 · PMC12712771 · PMID 40964745

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In contrast to a former study by Alsquati and colleagues [ 56 ] which showed a trend towards a higher abundance of clathrin‐related proteins in the aged human cortex, clathrin showed a significant enrichment in our young subjects, likely to Dynamin‐1 and the Dynamin‐1‐like protein, potentially indicating a spatial difference in the level of clathrin‐associated proteins in the aging SNpc.

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