Circadian activity and sleep architecture in autism spectrum disorder mouse model with <i>Chd8</i> mutation.

We found that male Chd 8 +/− mice showed a trend toward a slightly shorter circadian period compared to WT mice ( p = 0.0651, effect size = 0.71, mean difference= −0.06557, CI = −0.1335 to 0.0043; Figure 1D ), although the absolute difference was minimal (approximately 5 min), suggesting that this alteration is unlikely to meaningfully affect the sleep phase.

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