Mitochondrial polarization and redox homeostasis couple glycolysis-to-OXPHOS metabolic rewiring to lifespan extension in <i>C. elegans</i>.

A significant trend toward progressively longer lifespan was observed in conditions that shift metabolism away from glycolysis (log-rank trend X2 = 21.97, df = 1, p < 0.0001), with median lifespan on glucose at 13.0 days, in control media at 15.5 days, and 17.0, 18.0, and 17.5 days on galactose, 2-DG, and galactose + 2-DG, respectively ( Figure 1A )(n = 60 per condition, no censoring).

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