Metformin mitigates aortic valve degeneration in an ex vivo three-dimensional tissue model.

Sci Rep · 2025 · PMC12715251 · PMID 41408106

Europe PMC DOI

hedged sentence

0.0571

closest p · 1.1× alpha

0.0571

boldest claim

The sentences

did not reach statistical significancep = 0.0571so close (0.05 < p ≤ 0.1)

While quantification of areas stained for ALP did not reach statistical significance, it suggested a trend towards reduced ALP activity by metformin treatment (Fig. 2 A, right , p = 0.0571).

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