The association of polypharmacy with intrinsic capacity: an analysis of the WHO ICOPE pilot data from Lianyungang, China.

Concurrently, a positive trend was observed between increasing medication count and impairments in locomotion, nutritional risk, and hearing, although these associations failed to reach statistical significance.

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The high IC group (<2 points) had the lowest median number of medications (1.6), followed by the medium IC group (2–3 points) with 1.9 medications, and the low IC group (≥4 points) had the highest (2.2 medications), demonstrating an increasing trend in medication numbers with decreasing IC levels. 3.3 Subgroup analyses We conducted subgroup analyses to evaluate potential effect modifiers in the medication count-diminished intrinsic capacity association.

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