Endothelium-Independent Relaxation of Alkaloid Boldine in Isolated Aortas From Normotensive and Hypertensive Rats: Participation of Ca<sup>2+</sup> Channels.

TEA at a concentration of 10 mM (Figure 3a ), LogEC50 −4.029, which acts as a nonselective blocker of K + channels, had a significant shift of the curve to the right, whereas at a concentration of 1 mM (Figure 3b ), LogEC50 −4.470 the detachment was slightly significant, suggesting a reduction in the relaxing effect of the compound; however, at both concentrations, there was no interference in the maximum effect.

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