Mineralocorticoid receptor antagonists for acute myocardial infarction: a systematic review and meta-analysis of randomised controlled trials.

Heart failure Across the trials reporting HF outcomes, MRA therapy was associated with a numerically lower incidence of new or worsening HF events; however, this difference did not reach statistical significance (OR 0.76, 95% CI 0.52 to 1.12, p=0.17) ( figure 1C ).

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The CLEAR trial contributed a significant 32% risk reduction (OR 0.68, 95% CI 0.49 to 0.96), whereas EPHESUS showed borderline significance (OR 0.87, 95% CI 0.74 to 1.01). 10 15 Heterogeneity persisted (I2=72.13%, τ2=0.15).

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