Fecal microbiota composition and function are associated with anxiety and depression in patients with inflammatory bowel disease.

Richness and composition of fecal microbiota in IBD patients with anxiety or depression Compared with IBD patients without anxiety or depression (NonAD), alpha diversity and beta diversity of fecal microbiota in IBD patients with anxiety (alpha diversity, P = 0.08, Fig 1A ; beta diversity, R 2 = 0.021, P = 0.393, Fig 1B , S2a Table in S1 File ), depression (alpha diversity, P = 0.24, Fig 1C ; beta diversity, R 2 = 0.018, P = 0.533, Fig 1D , S2b Table in S1 File ) did not reach statistical significance.

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