highly significantp < 0.001
For the expanded Center 2 external validation cohort ( n = 102), all models demonstrated highly significant improvements with the comprehensive vs targeted approach ( p < 0.001).
For the expanded Center 2 external validation cohort ( n = 102), all models demonstrated highly significant improvements with the comprehensive vs targeted approach ( p < 0.001).
While most models demonstrated subtle improvement trends, the majority did not reach statistical significance for F1 and recall metrics (most comparisons n.s.).