Role of innate immune and inflammatory signaling in West Nile virus tropism and neuronal and glial cell death.

Regarding loss of neurons, quantified on the basis of HuC/HuD immunostaining, although the diminution of 17% at 7 dpi in WNV NY99 -infected cells did not reach statistical significance (Fig. 3 G), significant decreases were evidenced in WNV Fr2015 - and WNV Fr2018 -infected cells (34% and 36%, respectively) (Supplemental Fig. 4G), demonstrating neuronal death.

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