Combining topical and intravenous tranexamic acid in cardiac surgery: does it really matter? - a systematic review and meta-analysis.

Int J Cardiol Heart Vasc · 2026 · PMC12719039 · PMID 41438392

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did not reach statistical significanceno p-value reported

[ 12 ] observed lower 24-hour blood loss in the combined therapy group, though the difference in mean values did not reach statistical significance.

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