Barely Significant
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Effect of diamine oxidase (DAO) enzyme dietary supplementation in subjects with insomnia symptoms and single nucleotide polymorphisms of the <i>AOC1</i> gene: a randomized double-blind placebo-controlled study.

Sleep Med X · 2026 · PMC12721298 · PMID 41437955

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Interesting, sleep efficiency and use of sleep medication showed statistically significant within-group differences in the DAO group only for the dosing regimen of once-daily, whereas within-group differences in the placebo group did not reach statistical significance.

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