A Common Ancestry-Specific Sodium Channel Variant Increases Susceptibility to Drug-Induced QTc Prolongation: Evidence From a Large Biobank.

This contrasts with the findings of our previous study’s 1479-subject cohort, which did not reach statistical significance. 3 Furthermore, S/Y heterozygotes were hypersensitive to drug-induced QT prolongation, recapitulating our previous in vitro findings. 3 Our study’s limitations include retrospective design and insufficient power to assess Y/Y genotype–QT-prolonging drug interactions.

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