Human adenosine deaminase type 2 deficiency enhances NK cell activation but impairs maturation and function.

J Clin Invest · 2026 · PMC12721890 · PMID 41480770

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a clear trendno p-value reported

In line with the phenomenon of lymphocyte exhaustion after persistent activation, there was a clear trend toward an exhausted NK cell phenotype in DADA2 ( Supplemental Figure 2B ).

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