Rare and common variants in ERAP1 and ERAP2 selected for in response to Yersinia pestis infection contribute to autoimmune disease including inflammatory bowel disease.

Mamm Genome · 2025 · PMC12722269 · PMID 41428259

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closest p · 1.0× alpha

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nominally significantp < 0.05actually significant

In the Southampton cohort, variant-level analysis identified 6 common variants that were nominally significant when testing between UC versus CD ( p < 0.05; empirical permuted p-value).

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