STAT3 Signaling Mediates Agomelatine Restoration of Prefrontal Cortex Synaptic Plasticity in Chronic Social Defeat Stress Mice.

Mol Neurobiol · 2025 · PMC12722381 · PMID 41428145

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a decreasing trendno p-value reported

Although IL-6 levels showed only a decreasing trend following agomelatine treatment, this reduction was not reversed by STAT3 inhibition.

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showed a trendno p-value reported

Susceptible mice showed a trend of reduced GSK3β phosphorylation, which was significantly restored by agomelatine, indicating normalization of GSK3β activity via inhibitory phosphorylation independent of total protein levels.

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