Peripheral cyclical expression of GABA-A receptor subunit genes and menstrual cycle affective change: a dimensional, transdiagnostic study.

GABRD expression as a moderator of cyclical symptom trajectory All but one GABRD × cycle-time interactions predicting depression, anxiety, irritability, or SI failed to reach significance (all ps > 0.05; Table S12 ).

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There was a nominally significant interaction between an individual’s degree of perimenstrual increase in GABRD expression (GABRD-AUCi) and cycle time, which correlated with a stronger quadratic shape of SI across the luteal phase ( Quadratic Interaction Est = −0.28, 95% CI = −0.54–0.01, p = 0.057).

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