Longitudinal association of retinal morphology and white matter progression in retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations.

Reduction in TMV was associated with reduced normalized white matter volume ( β = 0.021, 95% CI [0.006, 0.036], p = 0.0137), increased WMH volume ( β = −11.0, 95% CI [−17.4, −4.0], p = 0.0046), and a near-significant increase in mean diffusivity ( β = −0.017, 95% CI [−0.035, −0.001], p = 0.057).

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Finally, the association between TMV and MD, as a metric of microstructural integrity likely due to progressive small vessel ischemia, was borderline significant, potentially due to limited sample size, although further study is needed to substantiate this.

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