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Comparative analysis of lipid metabolism in trophoblast subpopulations in preeclampsia and <i>in vitro</i> hypoxia model.

Front Mol Biosci · 2025 · PMC12722821 · PMID 41446579

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In EVT, preeclampsia induced pronounced changes in cholesterol transporter expression: ABCG1 was significantly downregulated (95th percentile CPM: Ctrl = 335.2; PE = 146.0, p = 3.60e-07), while ABCA1 showed a trend toward upregulation (95th percentile CPM: Ctrl = 261.4; PE = 528.2, p = 0.11) ( Figure 3C ; Supplementary Figure S5 ). 3.4 Analysis of differentially expressed genes in BeWo b30 cells following hypoxia induction Hypoxia induction using the oxoquinoline derivative in BeWo b30 cells resulted in changes in the expression of 4,879 genes, of which 2,562 were upregulated and 2,317 were downregulated (see Figure 4 ).

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