Cryptotanshinone targets tumor-immune-microbiome axis to suppress colorectal cancer.

For Figure 4B , IL-1β levels showed no significant differences among the three groups (P > 0.05), though the CTS group exhibited a decreasing trend compared to the Model group.

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In summary, while CTS treatment did not induce significant changes in the overall proportions of CD3 + , CD4 + , CD8 + , or cytotoxic T cells, it showed a clear trend of reducing inflammatory cytokines and significantly alleviated T cell exhaustion, as evidenced by the reduction in PD-1+ T cells.

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