Cerebrospinal fluid ctDNA clarifies clonal divergence: leptomeningeal flare of <i>EGFR</i>-mutant disease after switch to selpercatinib for acquired <i>RET</i> fusion.

J Liq Biopsy · 2025 · PMC12723369 · PMID 41446706

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showed a trendno p-value reported

When the treatment was switched back to osimertinib, the patient's clinical symptoms improved rapidly, and head contrast-enhanced MRI showed a trend toward resolution of the brain metastases ( Fig. 2 ).

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Cerebrospinal fluid ctDNA clarifies clonal divergence: leptomeningeal flare of &lt;i&gt;EGFR&lt;/i&gt;-mutant disease after switch to selpercatinib for acquired &lt;i&gt;RET&lt;/i&gt; fusion.

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Cerebrospinal fluid ctDNA clarifies clonal divergence: leptomeningeal flare of <i>EGFR</i>-mutant disease after switch to selpercatinib for acquired <i>RET</i> fusion.