Furthermore, our data showed that several clinical parameters, including fasting glucose, HbA1c, and systolic blood pressure, showed significant or near-significant improvements after 6 months of SGLT2i treatment, whereas the expression of plasma-derived EV miRNAs, including miR-425-5p, remained unchanged for up to 12 months.
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Extracellular vesicle miR-425-5p promotes visceral fat reduction via DACT1 suppression in SGLT2i-treated diabetes.
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