Global, regional, and national burden of ischemic heart disease and ischemic stroke and their risk factors in youths and young adults aged 15-39 years (1990-2021): a comparative analysis of risk factors from global burden of disease study 2021.

After calculating the AAPC between 1990 and 2021, we observed a positive trend in age-standardized incidence (0.25% [95% CI, 0.21% to 0.30%], p < 0.001) and prevalence rates (0.20% [95% CI, 0.18% to 0.22%], p < 0.001) for IHD, while age-standardized mortality (−0.56% [−0.64% to −0.48%]) and DALY rates (−0.55% [−0.63% to −0.46%]) showed a decline.

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In IS, all age-standardized metrics exhibited a negative trend: incidence (−0.17% [−0.23% to −0.11%]), prevalence (−0.28% [−0.31% to −0.26%]), mortality (−1.07% [−1.16% to −0.99%]), and DALYs (−0.76% [−0.80% to −0.71%]), all with p < 0.001 ( Table 1 ).

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