Investigating the Effects of C1q‐Blocking Using a CDC‐Mutant 3D6 Antibody on ARIA in 5XE4 Mice

Reductions in complement gene expression, microhemorrhage deposition, and RBC extravasation did not reach statistical significance due to small sample size, however, our preliminary data suggests that blocking C1q‐binding on 3D6 may reduce the incidence of ARIA and further supports our hypothesis that early complement activation upon anti‐amyloid antibody binding to CAA contributes to ARIA.

also in 111,027 other papers