Genetic Variation of Aquaporin‐4 Associates with Cognition, Brain Volume, and Dementia Risk in a Large Community Cohort

Alzheimers Dement · 2025 · PMC12725697

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reached borderline significanceno p-value reported

This reached borderline significance from age 75 onwards, with heterozygotes displaying a 32% lower risk of incident AD dementia compared to homozygotes for the major allele (HR = 0.68, 95% CI [0.47, 1.00], p = 0.049, n = 551, incident cases = 35).

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