Frontal Cognitive Impairment and White Matter Hyperintensities in Probable Alzheimer’s Disease

Alzheimers Dement · 2025 · PMC12726336

Europe PMC

hedged sentence

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closest p · 1.2× alpha

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boldest claim

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showed a trendp =0.06so close (0.05 < p ≤ 0.1)

• However, the Digit Span Forward test showed a trend toward poorer performance in the moderate‐to‐severe WMH group ( p =0.06), suggesting possible frontal lobe vulnerability. • Depression and neuropsychiatric symptoms did not differ significantly between groups.

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