nominally significantp <5×10−6
Mixed effects models were employed to evaluate the rate of change in Mini‐Mental State Examination scores as a quantitative measure of disease progression Results Variants on chromosome 22q12.1 mapped to ZNRF3, MN1, PIPNB genes reached genome‐wide significance and together with nominally significant loci ( p <5×10−6) highlighted a role for neuronal resilience (both excitatory and inhibitory neurones) and anti‐viral immune responses.