Clinical data have demonstrated that the KD has a modest effect on markers of systemic inflammation, with an overall trend indicating significant decreases in C-reactive protein (CRP) but less meaningful impacts on IL-6 signaling ( 104 ).
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Metabolism of glioblastoma: a review of metabolic adaptations and metabolic therapeutic interventions.
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The median progression-free (PF) and overall survival (OS) rates were 12.5 months and nearly 30 months respectively, but these outcomes did not reach statistical significance, and the study was not sufficiently powered for efficacy endpoints.