Role of prior HPV infection and CD4 T-cell count in modulating cellular immune responses to a three-dose nonavalent HPV vaccine schedule in PWH receiving ART.

BMC Med · 2025 · PMC12729619 · PMID 41444940

Europe PMC DOI

hedged sentence

0.0780

closest p · 1.6× alpha

0.0780

boldest claim

The sentences

did not reach statistical significancep = 0.078so close (0.05 < p ≤ 0.1)

The mean increases in the percentage of the polyfunctional CD8 T-cell subset in the > 500 CD4/ μL group were + 0.037 (95% CI: − 0.005, + 0.079), with a difference compared to ≤ 500 CD4/μL of + 0.038 (95% CI: − 0.004; + 0.080) that did not reach statistical significance ( p = 0.078), and a similar trend was observed, with a Δ of + 0.165 95%CI ( p = 0.241), at T2.

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