Chlorogenic Acid Alleviates the Detrimental Effects of Concurrent Hyperglycemia and Chronic Stress on Brain Homeostasis by Modulating Antioxidative Defense in Adult Zebrafish.

Antioxidants (Basel) · 2025 · PMC12730118 · PMID 41462586

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an increasing trendno p-value reported

NRF2 content of the CUMS+D group demonstrated an increasing trend following CGA administration at all concentrations tested, reaching a significant change only at the maximum dose (200 mg/kg, Figure 4 A).

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did not reach statistical significanceno p-value reported

The expression of sod1 was unmodified by CGA treatment, whereas a trend toward increase was observed for catalase and gpx expression levels, which did not reach statistical significance.

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