Early MRI-Derived Volumetric Thresholds Predict Response and Guide Personalization in HER2-Positive Breast Cancer: A Retrospective Study.

Predictive Performance of δV1 and δL1 Receiver operating characteristic (ROC) analysis demonstrated superior predictive accuracy with δV1 (AUC = 0.745) (95% CI, 0.642–0.847) than with δL1 (AUC = 0.634) (95% CI, 0.512–0.757), though the difference was marginally non-significant ( p = 0.123) ( Figure 3 ).

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57.4%), although the difference failed to reach significance. 3.3.

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After δV1 stratification, the pCR rate gap between HER2 2+ and HER2 3+ patients approached significance in the δV1-defined responder subgroups.

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