Bile Acid Analogs with Anti-Germination Activities for Prophylaxis of <i>Clostridioides difficile</i> Infection Alter Bile Acid Homeostasis in the Enterohepatic Cycle.

When comparing the ratio of total unconjugated and conjugated BAs, both treatment groups demonstrated a significant trend towards lower ratios of unconjugated–conjugated BAs in the liver whereas higher ratios of unconjugated–conjugated BAs were noted in the feces, compared to the control group ( Figure 2 B).

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