Tumoral and Peritumoral Radiomics for Preoperative Prediction of Visceral Pleural Invasion in Lung Adenocarcinoma.

Notably, although not retained in the final models, the lesion major axis length showed a significant univariate association with VPI ( p < 0.001), while density exhibited a trend toward significance ( p = 0.055), consistent with their recognized role in pleural invasiveness.

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Density also showed a trend toward significance in predicting VPI, consistent with prior reports [ 8 , 13 , 14 , 22 ], but was excluded due to its high correlation with histotype, which had a stronger association with VPI and effectively incorporated its predictive contribution.

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