Kynurenic Acid Analog Attenuates the Production of Tumor Necrosis Factor-α, Calgranulins (S100A 8/9 and S100A 12), and the Secretion of HNP1-3, and Stimulates the Production of Tumor Necrosis Factor-Stimulated Gene-6 (TSG-6) but Does Not Alter IL-17 Levels in Whole-Blood Cultures of Patients with Spondyloarthritis.

Int J Mol Sci · 2025 · PMC12733208 · PMID 41465233

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did not reach statistical significanceno p-value reported

Treatment with 500 μM SZR72 modestly reduced SA1-induced EN-RAGE production to a median of 12,932 ng/mL; however, this reduction did not reach statistical significance.

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