highly significantp < 0.001
In the subgroup restricted to patients treated with ME DMT (n = 1025), the association between RoAD ≥ 4 and irreversible EDSS 6.0 remained strong and highly significant (adjusted HR 3.04, 95% CI 2.08–4.44, p < 0.001).
In the subgroup restricted to patients treated with ME DMT (n = 1025), the association between RoAD ≥ 4 and irreversible EDSS 6.0 remained strong and highly significant (adjusted HR 3.04, 95% CI 2.08–4.44, p < 0.001).
The association with EDSS ≥ 6.0 showed a similar trend (HR 4.3, 95% CI 0.6–30.7) but did not reach statistical significance.