Synthetic Linear Lipopeptides and Lipopeptoids Induce Apoptosis and Oxidative Stress: In Vitro Cytotoxicity and SAR Evaluation Against Cancer Cell Lines.

Pharmaceuticals (Basel) · 2025 · PMC12735945 · PMID 41471329

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a clear trendno p-value reported

Compounds 35 through 44 share an identical core structure but differ in fatty acid chain length (9–18 carbon atoms), demonstrated a clear trend: compounds with the longest fatty acid chains ( 43 and 44 ) exhibited the highest cytotoxic activity across all investigated cell lines.

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