Allosteric Conformational Locking of Sestrin2 by Leucine: An Integrated Computational Analysis of Branched-Chain Amino Acid Recognition and Specificity.

Molecules · 2025 · PMC12735963 · PMID 41471815

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hedged sentence

0.1550

closest p · 3.1× alpha

0.1550

boldest claim

The sentences

did not reach statistical significancep = 0.155not close (p > 0.1)

In contrast, the minor difference between leucine and isoleucine (~3.1 kcal/mol) did not reach statistical significance ( p = 0.155) with the current sample size of three replicates.

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