Class A scavenger receptor MARCO negatively regulates Ace expression and aldosterone production.

Elife · 2025 · PMC12736925 · PMID 41439503

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highly significantno p-value reported

Strengths: If properly demonstrated and validated, the fact that tissue-resident macrophages can exert physiological functions and influence endocrine systems would be highly significant and could be amenable to novel therapies.

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did not reach statistical significanceno p-value reported

We observed an increase in Ace expression in the Marco-deficient MPI co-cocultures but not WT, though this did not reach statistical significance.

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