The Effect of Deep Sedation with High Flow Nasal Oxygen Therapy on the Transcutaneous CO<sub>2</sub> and Mitochondrial Oxygenation: A Single-Center Observational Study.

Although pairwise comparisons at individual time points did not reach statistical significance, the spline-based mixed model did reveal a significant effect of time on mitoPO 2 .

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In another study, prolonged tcPCO 2 monitoring was also well tolerated, and the correlation between tcPCO 2 and PaCO 2 remained highly significant [ 19 ].

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