Real-world disproportionality analysis of sleep disturbances associated with antiseizure medications in epilepsy: a pharmacovigilance study.

Drug-event association analysis revealed several highly significant disproportionality signals (ROR >10), including eslicarbazepine with parasomnia (ROR = 20.9, 95% CI 2.42–166.93), oxcarbazepine with sleep paralysis (ROR = 11.04, 95% CI 3.69–33.04), perampanel with parasomnia (ROR = 21.42, 95% CI 2.58–178.01), topiramate with non-24-h sleep-wake disorder (ROR = 16.25, 95% CI 4.06–64.99), cenobamate with sleep talking (ROR = 13.7, 95% CI 3.07–61.24), and levetiracetam with increased need for sleep (ROR = 20.06, 95% CI 2.24–179.52).

also in 132,142 other papers

The remaining drugs showed a trend toward increased odds, though no statistically significant differences were detected. 3.4 Time to onset analysis of sAEs We compared the time to sAEs among patients receiving different ASMs.

also in 53,322 other papers