Preclinical evaluation of long-acting cabotegravir and rilpivirine for HIV post-exposure prophylaxis in a macaque model.

Although four macaques were protected, the efficacy estimate did not reach statistical significance.

also in 111,027 other papers

This window of vulnerability may be significant as it could facilitate early seeding of virus and its local expansion within a small founder virus population. 50 Such virus populations might be controlled during periods of therapeutic drug concentrations but could self-propagate when CAB and RPV are below inhibitory concentrations. 51 However, a pharmacological lag does not appear to be a viable explanation for the failures we observed in this study.

also in 13,097 other papers