Novel vascular damage markers in SLE: insights from carotid colour Doppler ultrasound and aortic oscillometry in the LUPCARD cohort.

Patients with an SDI ≥4 showed significantly higher ICA-RI (0.70 (0.68–0.77, IQR) vs 0.67 (0.60–0.72, IQR); p=0.032), while differences in ICA-PI (1.34 (1.22–1.69, IQR) vs 1.19 (1.01–1.51, IQR); p=0.057) approached, but did not reach statistical significance. cIMT correlated with age (r=0.47, p<0.001), MAP (r=0.302, p<0.001) and long-term medication with statin (r=0.26, p<0.001) and showed an inverse association with estimated glomerular filtration rate (eGFR) (r=−0.202, p=0.011). cIMT was furthermore lower in patients with ENA-positivity than in those without detectable ENA (0.78 mm (0.69–0.9, IQR) vs 0.84 mm (0.74–0.95, IQR); p=0.012).

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ICA-RI also remained significantly higher in patients with elevated CRP (p adj =0.016), while the correlation of ICA-PI with CRP showed a trend toward significance (p adj =0.058).

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