Aging-dependent reduction of KAT7/HBO1 activity impairs imMKCL-based platelet production by promoting immune properties.

ST-C imMKCLs exhibited significantly elevated γH2AX levels following KAT7 inhibition, even in the absence of exogenous DNA damage, indicating that KAT7 inhibition results in spontaneous DNA damage and may impair DNA repair capacity following mitomycin C-induced damage, even though this difference did not reach statistical significance ( p = 0.08) ( Figure 5 E).

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