UGT1A1 and Sacituzumab Govitecan Toxicity: A Systematic Review and Meta-Analysis.

Clin Pharmacol Ther · 2026 · PMC12746514 · PMID 40936312

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Cases of febrile neutropenia were reported as severe (≥ 3 grade) toxicity, and data on febrile neutropenia were available only for metastatic breast cancer 14 , 22 – this showed a trend toward an increased risk of severe febrile neutropenia in UGT1A1*28 homozygous subjects in comparison to UGT1A1 wild‐type subjects (OR 2.64, 95% CI: 0.24–28.86, I 2 = 71) (Online Supplementary Content, Figure S2 ).

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