Total caffeine intake is associated with lower serum α-Klotho and may impact its detection accuracy: Evidence from NHANES 2007 to 2016 and molecular docking.

In the fully adjusted model, compared to the lowest TCI group, KL levels decreased by −30.21 pg/mL (95% CI = −50.49 to −9.93 pg/mL) and −27.31 pg/mL (95% CI = −51.94 to −2.67 pg/mL) in the third and fourth groups, respectively, indicating a significant trend ( P for trend = .005).

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