Aspirin plus clopidogrel versus aspirin alone in patients with mild-to-moderate stroke: A systematic review and meta-analysis.

Medicine (Baltimore) · 2025 · PMC12747045 · PMID 41465965

Europe PMC DOI

hedged sentences

0.0700

closest p · 1.4× alpha

0.0700

boldest claim

The sentences

did not reach statistical significanceP = .07so close (0.05 < p ≤ 0.1)

DAPT was associated with a reduced risk of recurrent ischemic stroke compared to aspirin alone, however, the results did not reach statistical significance (10.5% with DAPT vs 12.9% with aspirin monotherapy, RR: 0.65, 95% CI: 0.41–1.04, P = .07, I 2 = 57%; Fig. 1 B).

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a nonsignificant trendno p-value reported

Conclusion DAPT with aspirin plus clopidogrel showed a nonsignificant trend toward reducing the risk of END and recurrent ischemic stroke.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.